The loss of fulfillment

I recently started reading The Inheritance of Loss by Kiran Desai. I was taken aback by the question which was put forth by the author in the book.

Could fulfillment ever be felt as deeply as loss?

Could it? When you are happy, when you are the best at you work, when you are contented, when you are at life's prime, do you feel fulfilled?
Do we feel that our life is complete? We compromise. On many things. Career. Family life. Love. Friendship. Sleep. Food. Health. We compromise on everything once in a while to keep things rolling.Obviously, these compromises cannot always be a win-win situation.

So, when do we feel fulfilled? We might have all the fun, roam all around, go on roadtrips every weekend, watch all the movies in town on Opening Night, eat all the different delicacies of each cuisine, spend all your money, time and energy on your friends.. But, what makes a person feel fulfilled?

Whatever happened to roti, kapda aur makaan phrase?

Coming to the question I was talking about, could fulfillment ever be felt as deeply as loss? Could it? Really?

I don't think so.